Views: 0 Author: Site Editor Publish Time: 2023-01-30 Origin: Site
Hydroxypropyl-β-cyclodextrin (HP-β-CD) is a chemical substance with a specific molecular structure and use. It has the molecular formula (C42H70O35)-HX+(C3H7O2)X, molecular weight 1431-1806, and purity ≥98%. Hydroxypropyl-β-cyclodextrin is a cyclodextrin derivative obtained from 7 glucose units forming a lipophilic cavity by substitution reaction of 2-hydroxypropyl.
Its physicochemical properties include a melting point of 278°C (dec.), a boiling point of 400°C, a density of 1.05 at 20.3°C, a refractive index of 125° (C=1, H2O), a solubility in water of 45% (w/v), and the form of a clarified, colourless solution, white to slightly yellow in colour, which has a spinning property.
Typical Properties
| Item | Specifications |
| Appearance | white powder,sweet,indodorous nontoxic |
| Assay | ≥99% |
| Theaveragesubstitution | perfect |
| Moisturecontent | ≤2.0% |
| ResidueonIgnition | ≤2.0% |
| Heavymetal(Pb) | ≤0.0025% |
| AS | ≤0.0002% |
| Thetotalnumberofgerm | ≤1000 |
| Thetotalnumberofmould | ≤100 |
| Pathogenicbacteria | Non |
Characteristics and Uses
The introduction of hydroxypropyl breaks the intramolecular cyclic hydrogen bonding of β-cyclodextrin, which overcomes the major drawback of poor water solubility of β-cyclodextrin while maintaining the cyclodextrin cavity. It is one of the most intensively researched and widely used cyclodextrin derivatives. It is mainly used in food, pharmaceutical and cosmetic industries.
1. In the field of food and spices, it can improve the stability and longevity of nutrient molecules, mask or correct the bad odour and taste of nutrient molecules of food, and can improve the production process and product quality. The solubility of the product in water is very good, substitution degree 4 and above can be miscible with water in any proportion, in 50% ethanol and methanol can also be dissolved.
2.used as a stabiliser, emulsifier, deodorant, etc. in cosmetic raw materials, can reduce the stimulation of organic molecules in cosmetics on the skin and mucous membrane tissues, enhance the stability of t
he active ingredients, prevent the volatility of nutrients, oxidation. It has a certain relative hygroscopicity.
3.in the pharmaceutical industry, due to the relative surface activity and haemolytic activity is relatively low and no irritation to the muscle, so it is an ideal injection solubiliser and drug excipient. It can improve the water solubility of insoluble drugs, increase the stability of drugs, improve the bioavailability of drugs, increase the efficacy of pharmaceuticals or reduce the dosage, adjust or control the release rate of drugs, reduce the toxic side effects of drugs. It can be used for oral drug, injection, mucosal drug delivery system (including nasal mucosa, rectum, cornea, etc.), transdermal absorption drug delivery system, lipophilic targeted drug carrier, and also can be used as protein protective agent and stabiliser.
Hydroxypropyl-β-cyclodextrin has a wide range of applications, mainly used in food, pharmaceutical and cosmetic industries.
In the pharmaceutical field, it is used as an ideal solubiliser for injection and drug excipient, which can improve the water solubility of insoluble drugs, increase the stability of drugs, improve the bioavailability of drugs, so as to adjust or control the release rate of drugs and reduce the toxic side effects of drugs. In addition, it can also be used in the field of food and flavouring to improve the stability and longevity of nutritional molecules.
Packaging and Shipping
Bags: 25kg/drum
Storage
It should be sealed and shaded to be stored in a dry, cool, well ventilated place.
If you have any further questions about HP-β-CD, please feel free to contact us and look forward to your feedback.